The highlight of the season was the first night game in Major League baseball history when the Reds behind the arm of Paul Derringer prevailed over the Philadelphia Phillies 2-1 under the lights at Crosley Field in Cincinnati.
The next day, on December 14, the club traded infielder Mark Koenig and pitcher Allyn Stout to the New York Giants in exchange for shortstop Billy Myers and cash.
Myers hit .313 and 10 home runs with the St. Louis Cardinals affiliate, the Columbus Red Birds during the 1934 season.
Early in 1935, Cincinnati acquired shortstop Eddie Miller from the Springfield Pirates of the Middle Atlantic League.
In mid-April, one day before the regular season started, the Reds returned first baseman Johnny Mize to the St. Louis Cardinals after he suffered a groin injury, nullifying the trade.
Late in the month, Cincinnati purchased infielder Billy Sullivan from the St. Paul Saints of the American Association.
In May, the club struggled, earning a record of 3–9 to begin the month, dropping their overall to 10-16 and into sixth place, eight games behind the pennant leading New York Giants.
During their winning streak, on May 24, the Reds hosted the Brooklyn Dodgers in what was the first night game in Major League history.
During the month of June, Cincinnati returned pitcher Danny MacFayden to the New York Yankees and sold little used infielder Tony Piet to the Chicago White Sox.
Catcher Ernie Lombardi led the club with a .343 batting average, while hitting 12 home runs and 64 RBI in 120 games.
Infielders Coaches Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg.