Weakened by its interaction with Cuba, the storm soon regained strength and made its final landfall near Cabo Gracias a Dios in Honduras on October 25.

Flooding and landslides in Jamaica took their toll on property, agricultural interests, and infrastructure; fruit growers on the island sustained about $2.5 million (1935 USD) in losses.

The storm did the most damage along the Tiburon Peninsula of southwestern Haiti, where catastrophic river flooding took the lives of up to 2,000 individuals, razed hundreds of native houses, and destroyed crops and livestock.

Reported at the time to be the worst flood in the nation's history, the disaster decimated banana plantations and population centers after rivers flowed up to 50 ft (15 m) above normal.

The hurricane forecast center in Jacksonville, Florida issued its first advisory on the storm late on October 20, following ship reports of winds approaching and exceeding gale-force.

[2] Due to low environmental air pressures and the large size of the cyclone, intensification was gradual as the storm approached Jamaica, eventually making landfall on the eastern side of the island, just west of the Morant Point Lighthouse, at 13:00 UTC on October 21.

[1][2] At around 18:00 UTC on October 22, the hurricane made landfall near Santiago de Cuba at its initial peak intensity, with winds of 85 mph (140 km/h).

Steered by persistent high-pressure ridging over the eastern United States and western Atlantic, the cyclone would maintain this highly unusual path for the remainder of its duration in open waters.

[2][3] On the morning of October 24, the barometer aboard a ship in the storm's eye fell to 988 hPa (29.2 inHg), its lowest recorded pressure.

[2] It matched its previous peak intensity at 12:00 UTC on October 25 as it approached Cabo Gracias a Dios on the border of Honduras and Nicaragua.

[2][3] The mountainous terrain of Central America worked to diminish the storm, which curved westward and steadily lost force, though observation of its decay was minimal.

[2] The hurricane affected Jamaica, Haiti, Cuba, Honduras, and North Nicaragua along its unusual path, killing an estimated 2,150 people.

[3] Heavy rainfall swelled rivers and triggered landslides;[5] the ensuing floods destroyed bridges, inundated many homes, and necessitated the rescue of trapped individuals.

[6] With telegraph communications cut to the hardest-hit areas and roads left impassable, the degree of destruction was initially uncertain, though it was described as "extensive".

Railways worked to secure non-essential trains, and residents of vulnerable coastal towns, including Caimanera, fled their homes in search of safer ground.

[11][12] The hurricane subjected eastern parts of the island to intense gales, measured at over 70 mph (110 km/h) at Santiago de Cuba before the anemometer failed.

[17][18] Populations of valley villages were believed to have been wiped out as rains sent the streams from the channels, demolishing the frail, thatched huts of the natives.

[23] Many hundreds of individuals were stranded by raging flood waters in the Cortés region, clutching to trees and rooftops as they awaited uncertain rescue.

[24] Overall, the hurricane inflicted about $12 million in damage across Honduras (including the agricultural impacts),[21] resulted in about 150 deaths,[1] and destroyed the homes of thousands of residents.

[23] Banana farms were heavily damaged around Cabo Gracias a Dios, occupied by both nations, and according to early reports in that area, all but a handful of dwellings were destroyed.