[1] Illinois voted for the Democratic ticket of Franklin D. Roosevelt and John Nance Garner.

Democrat J. Hamilton Lewis won reelection to a second consecutive, and third overall, term in the United States Senate.

[2] Challenging both Democratic nominee Henry Horner and Republican nominee Charles W. Brooks, Republican former Chicago mayor William Hale Thompson ran on the Union Progressive Party of Illinois' ballot line.

The party ultimately nominated Charles W. Hadley, who had been the distant runner-up in the Democratic primary.

Hughes faced Republican former secretary of state William J. Stratton in a rematch of the 1932 race.

An election was held for three of the nine seats for Trustees of University of Illinois to six year terms.

[1][6] New Democratic members Homer Mat Adams, James Mansfield Cleary, and Louis C. Moschel were elected.

Robert J. Dunne was defeated John F. Tyrrell (1,157,312 votes to 709,625 votes) in a nonpartisan race to fill the vacancy left on the Circuit Court of Cook County by the resignation of fellow Democrat Francis S.

[1] Democratic nominee Francis J. Coyle defeated Republican nominee Albert M. Crampton (51,609 votes to 50,163 votes) to fill the 14th district vacancy left by death of J. Paul Califf.

[1] Despite dying before the election, Republican nominee William J. Emerson defeated Democratic nominee James B. Sheean (38,712 votes to 30,184 votes) to fill the 15th district vacancy left by death of Frank T.