Cincinnati struck first in the top of the 4th inning, as with two outs, Ival Goodman walked, then stole second base, putting him in scoring position.
The game would remain tied until the bottom of the 9th inning, as Yankees right fielder Charlie Keller hit a triple to right field with one out, putting the winning run on third base.
Derringer then intentionally walked Joe DiMaggio, putting runners on first and third, setting up a possible double play with Yankees catcher Bill Dickey batting next.
The next New York hitter, leadoff man Frankie Crosetti, grounded out to Reds shortstop Billy Myers, as Dahlgren scored from third base, giving the Yankees a 1–0 lead.
In the bottom of the 4th inning, Babe Dahlgren of the Yankees hit the first home run of the World Series, a solo shot to left field, as New York took a commanding 4–0 lead.
The Reds would only muster up two hits in the game, as Monte Pearson shut down Cincinnati, striking out eight batters, in the Yankees 4–0 win as New York took a 2–0 series lead.
New York got off to a quick start in the 1st inning, as leadoff batter Frankie Crosetti earned a walk, then moved to second base on a groundout by Red Rolfe.
In the bottom of the 1st inning, with two outs, the Reds Ival Goodman and Frank McCormick hit back-to-back singles, putting runners on first and third base.
Reds leadoff man Billy Werber then hit a single to center field, scoring Myers, moved Thompson to third base, and tying the game 2–2.
The next hitter, Joe DiMaggio, made the Reds pay for the walk, as he blasted a two-run home run to deep center field, restoring the lead for New York at 4–3.
Whitey Moore then pitched the final three innings for Cincinnati, allowing no hits or walks, however, the damage was done, as New York won the game 7–3 and took a 3–0 series lead.
After getting Joe DiMaggio to fly out to left field, the Yankees Bill Dickey hit his second home run of the series, extending the lead to 2–0.
After Ernie Lombardi struck out, Al Simmons hit a double to deep left-center field, moving McCormick to third base.
Hershberger then hit a short fly ball to center field, which dropped for a single, allowing Simmons to score and tying the game 2–2 while Myers moved to third.
Frey threw it to shortstop Billy Myers, who dropped the throw, allowing DiMaggio to be safe on the play, and Keller to score, as the Yankees cut the Reds lead to 4–3 with runners on first and second base.