The 1940–41 La Liga was the tenth season since its establishment.
After an absence of one season due to the damages in their stadium, Oviedo came back to La Liga.
With the arrival of the Francoism, in 1941 a law that forbid the use of foreign names like Athletic, Sporting or Racing was approved.
However, the clubs recovered their Royal patronages and started to use again the term Real in their denominations.
The match between Zaragoza and Castellón was played at Estadio Chamartín in Chamartín de la Rosa, while the one between Murcia and Deportivo La Coruña, in Campo de Fútbol de Vallecas, in Vallecas.