The team was led by head coach Frank Thomas, in his 11th year, and played their home games at Denny Stadium in Tuscaloosa and Legion Field in Birmingham, Alabama.
They finished the season with a record of nine wins and two losses (9–2 overall, 5–2 in the SEC) and with a victory in the Cotton Bowl Classic over Texas A&M.
Alabama then closed the regular season with a road victory over Miami and defeated Texas A&M in the Cotton Bowl Classic.
[2] [3] To open the 1941 season, Alabama defeated the Southwestern Louisiana Institute Bulldogs (now known as the Louisiana–Lafayette Ragin' Cajuns) 47–6 at Denny Stadium.
The Crimson Tide then played their second line and Don Salls scored their third touchdown of the afternoon on a 6-yard run to give Alabama a 20–6 halftime lead.
[4] The victory was Alabama's first against the Bulldogs and also marked the return of former Crimson Tide All-American Johnny Cain to Tuscaloosa as head coach of Southwestern Louisiana.
[6][7] In the first conference game of the season, Alabama was shut out 14–0 by the Mississippi State Maroons on homecoming at Denny Stadium for the second consecutive year.
Touchdowns were scored on a 19-yard Bill Murphy pass to Robert Patterson in the third and on a short Bruce run in the fourth.
[5][10] The Crimson Tide took a 13–0 halftime lead after touchdowns were scored on a 1-yard Don Salls run in the first and on an 8-yard reverse by Dave Brown in the second.
[5][12] Alabama scored all of their points in the first half for a 9–0 lead on a 21-yard George Hecht field goal in the first and on a 2-yard Don Salls touchdown run in the second.
[14] Alabama then scored their final points late in the third when Nelson intercepted a Frank Sinkwich pass and returned it 54 yards for a 27–7 lead.
[5][16] First half touchdowns were scored by Jimmy Nelson on a 20-yard run in the first and on a 22-yard pass from Russ Mosley to George Weeks in the second.
[16] Second half touchdowns were scored on a Nelson to Holt Rast reception in the third and on both a 25-yard Howard Hughes to Carl Mims pass and on a 23-yard Frank Martin run.
[5][19] Alabama scored first when Jimmy Nelson took a Bob Glass punt and then handed it to Dave Brown who returned it 60 yards for a touchdown.
[5][27][29] After an 85-yard punt return by Jimmy Nelson brought the ball to the Miami 5-yard line, Russ Craft scored on a 5-yard reverse for a 7–0 Alabama lead.