In its 12th season under head coach Ray "Gaumy" Neal, the team compiled a 6–2 record.
The team played its home games at the newly constructed Ira B. Blackstock Memorial Stadium in Greencastle, Indiana.
[1] The stadium was a gift from the widow of Ira B. Blackstock, a DePauw alumnus and university trustee who died in 1931.
[4] [13] The roster of the 1941 DePauw team included the following players:[3]
This college football 1940s season article is a stub.