Detroit outscored its opponents by a combined total of 195 to 43, and finished with a 7–2 record in its 17th year under head coach and College Football Hall of Fame inductee, Gus Dorais.
Significant games included victories over Indiana (14–7) and Oklahoma A&M (20–14) and a close loss to Arkansas (6–9).
[2] During a ceremony at halftime on November 8, Butler, at age 71, was honored for his many years of service as the school's trainer and track and boxing coach; he was presented with $600 in cash, a radio, a "D" blanket, a trophy, a plaque, and scrolls.
[3] Center Vince Banonis, who was later inducted into the College Football Hall of Fame, was the team captain.
[8] Louis Harrington picked three Titans as first-team players on his All-Michigan football team for 1941: Vince Banonis, halfback Elmer L. "Tippy" Madarik, and guard Thomas McLoughlin.