The team compiled a 7–3–1 record (3–1 against conference opponents), tied for third place in the conference, and outscored all opponents by a total of 178 to 88.
[1][2][3] Three Hardin-Simmons players were selected by the conference coaches as first-team players on the 1941 All-Border Conference football team: quarterback Murray Evans; end H.C. Burrus; and tackle Truett Rattan.
93 (out of 681 teams) in the final rankings under the Litkenhous Difference by Score System for 1941.
[5] Warren B. Woodson was in his first season as the team's head coach.
Woodson was later inducted into the College Football Hall of Fame.