In its third and final season under head coach Joe Sheeketski, the team compiled a 4–4–2 record and was outscored by a total of 104 to 103.
[1] Two Holy Cross players were selected by the United Press as first-team players on the 1941 All-New England football team: quarterback Francis L. Saba and fullback John Grigas.
73 (out of 681 teams) in the final rankings under the Litkenhous Difference by Score System for 1941.
[3] The team played its home games at Fitton Field in Worcester, Massachusetts.
This college football 1940s season article is a stub.