The team compiled an 8–2 record (5–0 against Big 6 opponents), won the Big 6 championship, lost to Fordham in the 1942 Sugar Bowl, outscored all opponents by a combined total of 226 to 39, and was ranked No.
Don Faurot was the head coach for the seventh of 19 seasons.
[1][2] The team played its home games at Memorial Stadium in Columbia, Missouri.
The team's leading scorer was junior halfback Bob Steuber with 67 points.
Three others (quarterback Maurice Wade, end Bert Ekern, and tackle Robert Brenton) were named to the second team.