In their second season under head coach Red Sanders, the Commodores compiled an 8–2 record (3–2 in conference play) and outscored opponents by a total of 260 to 89.
On November 9, Vanderbilt played the school's 439th game and defeated Georgia Tech, 14–7, for the 300th win in program history.
Two Vanderbilt players were selected by the Associated Press (AP) and the United Press (UP) as first-team players on the 1941 All-SEC football team: center Bob Gude (AP-1, UP-1) and fullback Jack Jenkins (AP-1, UP-1).
14 (out of 681 teams) in the final rankings under the Litkenhous Difference by Score System for 1941.
[6] The Commodores played their home games at Dudley Field in Nashville, Tennessee.