In their second and final season under head coach Frank Loebs, the Bears compiled a 4–5 record (1–3 against MVC opponents), finished fifth in the MVC, and were outscored by a total of 165 to 150.
[1] The team played its home games at Francis Field in St. Louis.
The team was led by senior halfback Bud Schwenk.
During the 1941 season, Schwenk broke the national collegiate single-season records for completed passes (114) and yards of total offense (1,928).
198 (out of 681 teams) in the final rankings under the Litkenhous Difference by Score System.