The 1942–43 Coppa Italia was the tenth edition of the tournament and the last before the suspension of football competitions in Italy due to World War II related events.
After a short elimination round, 32 clubs were admitted to the final phase.
All the matches were played in a single leg with eventual replay on the model of the FA Cup, homefields were decided by a draw except for the final match in Milan.
The trophy was won by Torino, which defeated 4–0 Venezia in the final match, played at the San Siro in Milan on May 30, 1943.
Top scorers of the competition were Bruno Ispiro (Genova 1893), Valentino Mazzola (Torino) and Vittorio Sentimenti (Juventus).