The 1942–43 Cupa României was the tenth edition of Romania's most prestigious football cup competition.
The title was won by CFR Turnu Severin against Sportul Studențesc București.
The competition is an annual knockout tournament with pairings for each round drawn at random.
If a match is drawn after 90 minutes, the game goes in extra time, and if the scored is still tight after 120 minutes, there a replay will be played, usually at the ground of the team who were away for the first game.
The format is almost similar with the oldest recognised football tournament in the world FA Cup.