The 1942–43 Wyoming Cowboys basketball team represented the University of Wyoming in NCAA men's competition in the 1942–43 NCAA college basketball season.

Kenny Sailors of Hillsdale, Wyoming averaged 15.5 points per game and Milo Komenich averaged 16.7 points per game in leading the team to the championship.

St. John's won the eight-team National Invitation Tournament the night before, also at Madison Square Garden, and claimed it was better than Wyoming and that the NIT was a better event than the eight-team NCAA tournament.

[17] Ev Shelton talked Ned Irish, the promoter at Madison Square Garden, into hosting a showdown game, with proceeds going to the Red Cross.

Two days after winning the NCAA Championship at Madison Square Garden, Wyoming met St. John's in a Red Cross benefit game for the war effort, and the Cowboys won in overtime, 52–47.