The 1943 Copa Adrián C. Escober Final was the match that decided the winner of the fourth edition of the Copa Adrián C. Escobar, an Argentine domestic cup organised by the Argentine Football Association.

After the match ended tied 0–0, Huracán was declared winner 4–1 based on a penalty shootout.

[3][4] Bold indicates winning years This edition of the Cup was contested by the seven best placed teams of the 1943 Primera División season.

In the tournament, Huracán beat River Plate 1–0 and Independiente (on corner kicks awarded) at Estadio Monumental.

Platense beat Estudiantes de La Plata 1–0 (at Estadio Monumental) and Boca Juniors in semifinals (7–3 on corner kicks after a 1–1 draw) at San Lorenzo Stadium.