The 1943 Saint Mary's Pre-Flight Air Devils football team was an American football team that represented the United States Navy pre-flight school at Saint Mary's College of California during the 1943 college football season.
The team compiled a 3–4–1 record.
Spike Nelson was the head coach.
The team included 1941 Heisman Trophy winner Bruce Smith.
In the final Litkenhous Ratings, Saint Mary's Pre-Flight ranked 32nd among the nation's college and service teams with a rating of 90.5.