This was the first season the club played in the Mexican professional league.

The club had joined a year after the league began competition in 1943.

Puebla finished second in the league to Club Espana and managed to establishment itself as one of the countries powerful clubs.

1944-45 season was the first the club played in the First Division after being invited by the league in 1943.

[citation needed] Puebla Had by weeks in rounds 3 and 4th .