Wyoming was won by the Republican nominee, Governor of New York Thomas Dewey, running with Governor of Ohio John W. Bricker, by a 2.5% margin of victory, with 51.23 percent of the popular vote against incumbent Democratic President Franklin D. Roosevelt, running with Missouri Senator Harry S. Truman, with 48.77 percent of the popular vote, becoming the first Republican to win Wyoming since Herbert Hoover in 1928, sixteen years earlier.

[1] This election was conducted in the midst of The Second World War, which was going well for America and the Allied Powers, Dewey campaigned against The New Deal, arguing in support of a smaller government and repealing many of the wartime regulations on the economy, as the end of the war appeared in sight.

[2] Though many were weary of Roosevelt's long tenure, as Americans were used to Presidents only seeking two terms, Roosevelt's longstanding popularity would prove too difficult to overcome, and major American victories in Europe and the Pacific, such as The Liberation of Paris in France, and the Battle of Leyte Gulf in the Philippines gave Americans little to no reason to switch leadership in this election, and made Roosevelt unbeatable, with him leading Dewey in all pre-election polls.

Dewey flipped 4 counties that Roosevelt won in 1940; Teton, Natrona, Park, and Platte.

Despite his victory in this election, Dewey would go on to lose the state to Harry Truman in 1948, when he lost in an upset.