The 1945–46 Serie C was a special edition of Serie C, the third highest league in the Italian football league system.
Best clubs of Northern Italy were admitted as special guests into the 1945–46 Serie B-C Alta Italia.
Northern Italy sides were divided in several rounds (gironi).
The winners qualified to a tournament to determine the only team promoted to 1946–47 Serie B.
[1] Later other teams were admitted to Serie B to create a southern round.