In its 18th and final season under head coach Andrew Kerr, the team compiled a 4–4 record and outscored opponents by a total of 154 to 95.
[1][2] In Kerr's final game as Colgate's head coach, the team trailed 7–0 to Brown at halftime.
Kerr gave a speech asking his team to score three touchdowns in the second half.
53 in the final Litkenhous Difference by Score System rankings for 1946.
[4] The team played its home games at Colgate Athletic Field in Hamilton, New York.