The 1946 Cotton Bowl Classic was a postseason college football bowl game between the tenth ranked Texas Longhorns and the Missouri Tigers.

Texas was led by star quarterback, Bobby Layne.

Missouri had three touchdown runs from William Dellastatious, Howard Bennett, and Robert Hopkins with a touchdown catch from Roland Oakes, but the Tigers could not stop Layne, who went 11 of 12 for 158 yards.

[4][5] Pound sign (#) denotes national championship game.

† denotes College Football Playoff semifinal game ‡ denotes College Football Playoff quarterfinal game