The Toledo Rockets, led by first-year head coach Bill Orwig, finished in second place with a 6–2–2 record (4–0 against OAC opponents), including a victory over Bates in the first annual Glass Bowl game.
Three of the conference's head coaches, each serving their first year as a college head coach, were later inducted into the College Football Hall of Fame: Woody Hayes at Denison, Paul Hoernemann at Heidelberg, and Ed Sherman at Muskingum.
[3] Halfback Paul Davis and center Ralph Pickelsimer were named to the 1946 All-OAC football team.
[4] In their first season under head coach Bill Orwig, the Rockets compiled a 6–2–2 record, outscored their opponents by a combined total of 200 to 132, and defeated Bates, 21–12, in the first postseason Glass Bowl game.
[19] The 1946 Baldwin–Wallace Yellow Jackets football team represented Baldwin Wallace University of Berea, Ohio.
[34] In their first season under head coach Trevor J. Rees, the Golden Flashes compiled a 6–2 record and ranked fourth nationally among small-college teams with an average of 349.1 yards per game in total offense.
They also ranked fourth nationally in total defense, giving up an average of only 115.1 yards per game.
In their first season under head coach Paul Baldacci, the Zippers compiled a 5–4 record and were outscored by a total of 134 to 122.
[42] Woody Hayes, at age 33, was hired as Denison's head coach in March 1946.
He had been a high school coach before World War II and served as athletic officer at the Naval Academy in 1942.
[59] The Associated Press selected a 1946 All-Ohio Conference football team consisting of the following players: [62]