The 1946 Oklahoma City Chiefs football team represented Oklahoma City University as an independent during the 1946 college football season.
Led by Bo Rowland in his first as head coach, the team compiled a record of 10–1.
Oklahoma City was ranked second nationally among small-college teams with an average of 392.7 yards per game in total offense.
The Chiefs also ranked sixth nationally in total defense, giving up an average of only 121.5 yards per game.
31 among all college programs in the final Litkenhous Difference by Score System rankings.