In its ninth season under head coach George Munger, the team compiled a 6–2 record, was ranked No.
[1] The Quakers ranked third nationally in total defense, giving up an average of only 158.9 yards per game.
[4] Four Penn players received honors from the Associated Press (AP) or International News Service (INS) on the 1946 All-Eastern football team: center Chuck Bednarik (AP-1, INS-1); tackle B. Gallagher (AP-1); guard Robert Rutkowski; and halfback Maderak (INS-2).
[5] Chuck Bednarik and George Munger were inducted into the College Football Hall of Fame in 1969 and 1976, respectively.
[6][7] The team played its home games at Franklin Field in Philadelphia.