In their 11th season under head coach Ace Mumford, the Jaguars compiled a 9–2–1 record, won the SWAC championship, shut out four of 12 opponents, and outscored all opponents by a total of 390 to 95.
[1][2] The Dickinson System rated Southern in a tie with Lincoln (MO) as the No.
[3] Southern ranked first in scoring offense among the black college teams with an average of 30.75 point per game.
[3] Southern tackle Robert Smith was selected as a first-team player on The Pittsburgh Courier's 1946 All-America team.
[4] The team played its home games at University Stadium in Scotlandville, Louisiana (which has since been annexed into the Baton Rouge city limits).