First-seeded Pauline Betz defeated fifth-seeded Doris Hart 11–9, 6–3 in the final to win the women's singles tennis title at the 1946 U.S. National Championships.

[1][2] The tournament used two lists of players for seeding the women's singles event; one for U.S. players and one for foreign players.

Pauline Betz is the champion; others show in brackets the round in which they were eliminated.

[3][4]