The 1946 West Texas State Buffaloes football team was an American football team that represented West Texas State College (now known as West Texas A&M University) in the Border Conference during the 1946 college football season.
In their fourth and final season under head coach Gus Miller, the Buffaloes compiled a 5–5 record (3–4 against conference opponents), finished in fifth place in the Border Conference, and were outscored by a total of 132 to 121.
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