The 1949–50 Challenge Cup was the 49th staging of rugby league's oldest knockout competition, the Challenge Cup.

[1] Warrington beat Widnes 19–0 in the final played at Wembley in front of a crowd of 94,249.

In the match Albert Naughton, at centre for Warrington opposed his older brother Johnny, who was in the Widnes second row.

[2] This was the second successive Final that the losing side had failed to score.

[3] The Warrington scrum-half Gerry Helme won the Lance Todd Trophy for man-of-the-match.