Arsenal won the competition for the third time, beating Liverpool 2–0 in the final at Wembley, through two goals from Reg Lewis.
If scores were level after 90 minutes had been played, a replay would take place at the stadium of the second-named team later the same week.
The 25 winners from the fourth qualifying round were Billingham Synthonia, North Shields, Stockton, Netherfield, Fleetwood, Rhyl, Mossley, Bromsgrove Rovers, Witton Albion, Goole Town, Nuneaton Borough, Grantham, Hereford United, King's Lynn, Wealdstone, Tilbury, Gravesend & Northfleet, Walthamstow Avenue, Chelmsford City, Gillingham, Hastings United, Leytonstone, Romford, Weymouth and Gloucester City.
Those appearing in the competition proper for the first time were Fleetwood, Mossley, Nuneaton Borough, Wealdstone, Tilbury and Hastings United, while Goole Town had not featured at this stage since 1914–15.
The 44 First and Second Division clubs entered the competition at this stage along with Rotherham United, Reading and Bournemouth & Boscombe Athletic.
The London derby clash of Arsenal–Chelsea went to a replay, with Arsenal eventually winning their tie to meet Liverpool in the final at Wembley.
Future legendary Liverpool manager Bob Paisley was famously dropped for the final, even after scoring the winning goal against rivals Everton in the semi-final.