The Netherlands Football League Championship 1949–1950 was contested by 60 teams participating in six divisions.
The national champion would be determined by a play-off featuring the winners of the eastern, northern, two southern and two western football divisions of the Netherlands.
SV Limburgia won this year's championship by beating Blauw-Wit Amsterdam, Maurits, Ajax, sc Heerenveen and Enschedese Boys.
At the end of this season, the KNVB re-aligned the current system of Regional Divisions into 5 new Divisions for 1950–51, to be called Eerste Klasse A-E. Eerste Klasse South-I: Eerste Klasse South-II: Eerste Klasse West-I: Eerste Klasse Wëst-II: