In their third season under head coach Bowden Wyatt, the Cowboys compiled a 9–1 record (5–0 against Skyline Six opponents), won the Skyline Six championship, shut out six of ten opponents while averaging 38 points per game, and outscored all opponents by a total of 381 to 65.
[3] On November 5, 1949, the Cowboys defeated Colorado State College in Greeley by a score of 103 to 0.
[4] The team established the program's single-game records that still stand for points scored (103), touchdowns (15) rushing yardage (504), and total yards (871).
[5] Four Wyoming players were named to the Skyline Six All-Star team selected by the conference coaches for the Associated Press: tackle Charles Peterson; center Fred Taucher; fullback Walker "Sonny" Jones; and halfback Eddie Talboom.
[2] In 2000, Talboom, who played with the Cowboys from 1948 to 1950, became the first Wyoming player to be inducted into the College Football Hall of Fame.