It began on 14 January 1951 with the quarterfinals and concluded on 25 February 1951 with the replay final which was held at GSP Stadium.
APOEL won their 4th Cypriot Cup trophy after beating EPA 7–0 in the final.
In all rounds each tie was played as a single leg and was held at the home ground of one of the two teams, according to the draw results.
If extra time was drawn, there was a replay match.
Abandoned at the initial stage due to rain