The 1950–51 Southern Football League season was the 48th in the history of the league, an English football competition.
At the end of the previous season Colchester United and Gillingham were elected to the Football League.
Merthyr Tydfil were champions for the second season in a row, winning their third Southern League title.
Six Southern League clubs applied to join the Football League at the end of the season, but none were successful.
However, none were successful as only Workington of the North Eastern League received more votes than a League club (New Brighton).