The 1950 La Crosse State Indians football team was an American football team that represented the University of Wisconsin–La Crosse as a member of the Wisconsin State Teachers College Conference (WSTCC) during the 1950 college football season.
In their third season under head coach Clark Van Galder, the Indians compiled a perfect 10–0 record (6–0 against WSTCC opponents), outscored opponents by a total of 388 to 76, and won the WSTCC championship.
[1] The team played its home games at Memorial Field in La Crosse, Wisconsin.