Each of the eight geographical districts chose, by various methods, the team that would represent them in the NCAA Tournament.
The 1950 season marked the fourth NCAA Baseball Tournament, which consisted of the eight team College World Series.
For the first time, the College World Series was held in Omaha, Nebraska, which became the permanent home of the event.
District playoffs were not considered part of the NCAA Tournament, and the expansion to eight teams resulted in the end of regionals as they existed from 1947 through 1949.
The eight teams played a double-elimination format, with Texas claiming their second championship with a 3–0 win over Washington State in the final.