San Francisco's first NFL game was at Kezar Stadium on September 17 against the New York Yanks, as the 49ers fell short, losing by a score of 21–17.
They started the season 0–5 before recording their first NFL victory in a 28–27 win over the Detroit Lions at home.
The Niners played better after the 0–5 start, went 3–4 in their remaining 7 games to finish the season 3–9, and failed to qualify for the playoffs.
Quarterback Frankie Albert completed 50.7% of his passes, while throwing for 14 touchdowns and 23 interceptions.
Running back Joe Perry rushed for a team-high 647 yards and 5 touchdowns, while wide receiver Alyn Beals caught 22 passes for 315 yards, and 3 touchdowns.