The premiership was won by the Oakleigh Football Club, which defeated Port Melbourne by 19 points in the Grand Final on 30 September.
During the 1949 season, the Association had made the decision to re-affiliate with the Australian National Football Council.
Most notably, this meant that throwing the ball in general play was no longer legal.
Field Umpire Jack Cleary) As a consequence of joining the ANFC, the Association was permitted to send a representative team to the 1950 Brisbane Carnival.
The team was coached by Bill Faul (Prahran) and captained by Jack Whelan (Brunswick).