The 1951 Cal Poly Mustangs football team represented California Polytechnic State College—now known as California Polytechnic State University, San Luis Obispo—as a member of the California Collegiate Athletic Association (CCAA) during the 1951 college football season.
Led by second-year head coach LeRoy Hughes, Cal Poly compiled an overall record of 5–4–1 with a mark of 2–1–1 in conference play, tying for second place in the CCAA.
The Mustangs played home games at Mustang Stadium in San Luis Obispo, California.
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