The 1951 Challenge Desgrange-Colombo was the fourth edition of the Challenge Desgrange-Colombo.

It included eleven races: all the races form the 1950 edition were retained with the addition of Liège–Bastogne–Liège.

Paris–Tours moved from a spring slot to an autumn slot.

Louison Bobet won the competition by a single point to 1950 champion Ferdinand Kübler.

France won their first nations championship.