Each of the eight geographical districts chose, by various methods, the team that would represent them in the NCAA Tournament.
The 1951 season marked the fifth NCAA Baseball Tournament, which consisted of the eight team College World Series.
The College World Series was held in Omaha, Nebraska, which set a record for attendance of 27,789.
District playoffs were not considered part of the NCAA Tournament, and the expansion to eight teams resulted in the end of regionals as they existed from 1947 through 1949.
The eight teams played a double-elimination format, with Oklahoma claiming their first championship with a 3–2 win over Tennessee in the final.