Frank Sedgman defeated Vic Seixas 6–4, 6–1, 6–1 in the final to win the men's singles tennis title at the 1951 U.S. National Championships.

[2] The tournament used two lists of eight players for seeding the men's singles event; one for U.S. players and one for foreign players.

Frank Sedgman is the champion; others show the round in which they were eliminated.

[2]