The College World Series, held for the sixth time in 1952, consisted of one team from each of eight geographical districts and was held in Omaha, Nebraska at Johnny Rosenblatt Stadium as a double-elimination tournament.
Each of the eight geographical districts chose, by various methods, the team that would represent them in the NCAA Tournament.
The 1952 season marked the sixth NCAA Baseball Tournament, which consisted of the eight team College World Series.
District playoffs were not considered part of the NCAA Tournament, and the expansion to eight teams resulted in the end of regionals as they existed from 1947 through 1949.
The eight teams played a double-elimination format, with Holy Cross claiming their first championship with an 8–4 win over Missouri in the final.