[1] The original sixteen clubs of the 1959 Milli Lig took part in the 1959–60 edition, along with newly promoted Kasımpaşa, Şeker Hilal, Altınordu, and Feriköy.
Beşiktaş won their first league title, winning 11 matches by a 1-0 margin, a record at the time.
[1] Altınordu finished first in the Baraj Maçları, allowing them to stay in the Milli Lig.
Hacettepe and Adalet were not successful, earning relegation to the Ankara and Istanbul professional leagues respectively.
Adana Demirspor would become the first club from outside of the big three cities (Ankara, Istanbul, and İzmir) to compete in the Milli Lig during the following season.