The 1959 Cincinnati Reds season consisted of the Reds finishing in a fifth-place tie with the Chicago Cubs in the National League standings, with a record of 74–80, 13 games behind the NL and World Champion Los Angeles Dodgers.
The Reds played their home games at Crosley Field, where they attracted 801,298 fans, eighth and last in the Senior Circuit.
Mayo Smith, hired during the previous off-season, managed the Reds to a 35–45 start, seventh in the eight-team league.
He was replaced during the first All-Star break by Fred Hutchinson, manager of their Triple-A Seattle Rainiers affiliate, on July 9.
Infielders Other batters Coaches Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg.