The 1959 Holy Cross Crusaders football team was an American football team that represented the College of the Holy Cross as an independent during the 1959 college football season.
Eddie Anderson returned for the 10th consecutive year as head coach, his 16th year overall.
The team compiled a record of 6–4.
[1] All home games were played at Fitton Field on the Holy Cross campus in Worcester, Massachusetts.
Statistical leaders for the 1959 Crusaders included:[11]