The 1959 Los Angeles State Diablos football team represented Los Angeles State College—now known as California State University, Los Angeles—as a member of the California Collegiate Athletic Association (CCAA) during the 1959 college football season.
Led by ninth-year head coach Leonard Adams, Los Angeles State compiled an overall record of 7–3 with a mark of 3–2 in conference play, tying for second place in the CCAA.
The Diablos played three home games at the Rose Bowl in Pasadena, California and one home game at East Los Angeles College Stadium in Monterey Park, California.
[8] The following Los Angeles State players were selected in the 1960 NFL draft.
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