The 1959 Ohio State Buckeyes football team represented the Ohio State University in the 1959 Big Ten Conference football season.

The Buckeyes compiled a 3–5–1 record.

Ohio State: 127 yards total offense; 5 first downs; 8 punts for 333 yards; missed FGs from 58 and 50 yards Indiana: 179 yards total offense; 11 first downs; 7 punts for 290 yards