The 1959 United States Senate elections in Hawaii were held July 28, 1959.

Oren E. Long was given seniority based on his service as Governor of Hawaii.

Oren Long Democratic This election was for the Class 3 term expiring in 1963.

As of 2022, Tsukiyama's loss by a 2.8 point margin is the closest Republicans have come to winning this seat.

Following Long's victory, Governor William F. Quinn appointed Tsukiyama to the Hawaii Supreme Court.